The Influence of Raltegravir on Pravastatin Pharmacokinetics(GRAPPA)

Inclusion Criteria:

* Subject is at least 18 and not older than 55 years of age.
* Subject does not smoke more than 10 cigarettes, 2 cigars, or 2 pipes per day.
* Subject has a Quetelet Index (Body Mass Index) of 18 to 30 kg/m2.
* Subject is able and willing to sign the Informed Consent Form prior to screening evaluations.
* Subject is in good age-appropriate health condition.
* Subject has a normal blood pressure and pulse rate.

Exclusion Criteria:

* Documented history of sensitivity/idiosyncrasy to medicinal products or exci-pients.
* Positive HIV test.
* Positive hepatitis B or C test.
* Pregnant female or breast-feeding female.
* Therapy with any drug.
* Relevant history or presence of pulmonary disorders (especially COPD), car-diovascular disorders, neurological disorders (especially seizures and mi-graine), gastro-intestinal disorders, renal and hepatic disorders, hormonal disorders (especially diabetes mellitus), coagulation disorders.
* Fasting triglyceride levels \> 8.0 mmol/L
* Relevant history or current condition that might interfere with drug absorption, distribution, metabolism or excretion.
* History of or current abuse of drugs, alcohol or solvents.
* Inability to understand the nature and extent of the trial and the procedures required.
* Participation in a drug trial within 60 days prior to the first dose.
* Donation of blood within 60 days prior to the first dose.
* Febrile illness within 3 days before the first dose