This study is being done to understand the effects of calorie restriction and weight loss on muscle protein metabolism in adult men and women.
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Inclusion Criteria: * Healthy * BMI will be between 30 kg/m2 - 38 kg/m2 and waist circumference for women ≥ 88 cm and men ≥ 104 cm * Age 45 to 65 years. * Male and Female Exclusion Criteria: * Active coronary artery disease * BMI \< 30 kg/m2 Participation in structured exercise (\>2 times per week for 30 minutes or longer) * Smoking * Medications known to affect muscle metabolism (beta blockers) * Renal failure (serum creatinine \> 1.5mg/dl) * Chronic active liver disease (AST and ALT \> 3 times normal) * Fasting blood glucose \> 126 mg/dl * Anti-coagulant therapy (warfarin/heparin)