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Exosomes derived from umbilical cord mesenchymal stem cell for intranasal dropA placebo of exosomes derived from umbilical cord mesenchymal stem cell for intranasal drop

Xuanwu Hospital, Beijing33 participants1 site · ChinaCompletes Dec 2028

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Recruiting

A Safety and Efficacy of Intrathecally Administered ION283 in Patients With Lafora Disease

Phase 1Phase 2Lafora Disease

ION283

Berge Minassian10 participants1 site · United StatesCompletes Oct 2027

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Recruiting

Pegtibatinase as a Treatment for Participants With Classical Homocystinuria (HCU) Receiving Standard of Care Treatment

Phase 3Homocystinuria

PegtibatinasePlacebo

Travere Therapeutics, Inc.70 participants52 sites · United States, Australia, BelgiumCompletes Aug 2027

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Recruiting

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

Phase 2Alzheimer's Disease

VHB937VHB937Placebo

Novartis Pharmaceuticals407 participants74 sites · United States, Australia, CanadaCompletes Sep 2028

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Recruiting

Reducing the Burden of Cardiovascular Events With Antiplatelet Therapy in Patients With IntraCerebral Haemorrhage

Phase 3Intracerebral Haemorrhage

Aspirin 75 mg dailyPlacebo

Christian Medical College and Hospital, Ludhiana, India5,676 participants33 sites · IndiaCompletes Feb 2029

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Recruiting

Donepezil Versus Non-drug Treatment in Alzheimer's Disease.

Phase 3Alzheimer Disease, Early Onset

Donepezil

Assistance Publique - Hôpitaux de Paris240 participants1 site · FranceCompletes Aug 2026

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Recruiting

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

Phase 3Acute Treatment of Migraine

Rimegepant (PF-07899801)

Pfizer600 participants124 sites · United States, Poland, SpainCompletes Jul 2030

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Recruiting

A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Appear in Babies With Genetically Diagnosed Spinal Muscular Atrophy (SMA)

Phase 3Muscular Atrophy, Spinal

Salanersen

Biogen30 participants11 sites · United States, Australia, BrazilCompletes Nov 2028

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Recruiting

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Phase 3Primary Generalized Tonic-Clonic Seizures

XEN1101Placebo

Xenon Pharmaceuticals Inc.160 participants138 sites · United States, Argentina, AustraliaCompletes Apr 2027

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1–15 of 151

Explore/neurology CNS brain disease

Status

Phase

Pre-filtered to show active, later-stage trials with the strongest clinical signal.

151 results for “neurology CNS brain disease” · Recruiting · Phase 3 · Phase 2

Page 1 of 11

Recruiting

Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's Disease

Phase 3Alzheimer Disease

Combined metabolic activatorsCollagen and maltodextrin

ScandiBio Therapeutics AB845 participants8 sites · Turkey (Türkiye)Completes Sep 2026

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Recruiting

A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease

Phase 3Parkinsons Disease (PD)

bemdaneprocelSham surgery

BlueRock Therapeutics102 participants43 sites · United States, Australia, CanadaCompletes Mar 2027

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Recruiting

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

Phase 2Focal EpilepsyEpilepsyRefractory Focal Epilepsy

RAP-219

Rapport Therapeutics Inc.30 participants7 sites · United StatesCompletes Feb 2028

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Recruiting

Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage

Phase 2Cerebral Amyloid AngiopathyIntracerebral Hemorrhage Lobar

Colchicine 0.5mgMatching placebo

Huashan Hospital80 participants3 sites · ChinaCompletes Dec 2027

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Recruiting

A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)

Phase 3Covert Brain Infarction

acetylsalicyclic acid (ASA)ClopidogrelRosuvastatin+1 more

Aarhus University Hospital1,652 participants14 sites · Denmark, Germany, NorwayCompletes Sep 2031

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Recruiting

Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Small Vessel Stroke

Phase 3Ischemic Stroke

Atorvastatin 40mgRosuvastatin 20mg

Kafrelsheikh University600 participants1 site · EgyptCompletes May 2026

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Recruiting

The Effect of CB-Exo-A600 in Mild to Moderate Alzheimer's Disease

Phase 1Phase 2Mild to Moderate Alzheimer's Disease

Exosomes derived from umbilical cord mesenchymal stem cell for intranasal dropA placebo of exosomes derived from umbilical cord mesenchymal stem cell for intranasal drop

Xuanwu Hospital, Beijing33 participants1 site · ChinaCompletes Dec 2028

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Recruiting

A Safety and Efficacy of Intrathecally Administered ION283 in Patients With Lafora Disease

Phase 1Phase 2Lafora Disease

ION283

Berge Minassian10 participants1 site · United StatesCompletes Oct 2027

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Recruiting

Pegtibatinase as a Treatment for Participants With Classical Homocystinuria (HCU) Receiving Standard of Care Treatment

Phase 3Homocystinuria

PegtibatinasePlacebo